Effect of quercetine and ascorbic acid on cytochrome P450 2E1 and oxidative stress in the liver of guinea pigs with type 2 diabetes mellitus

and TAG almost to values noted in control rats. These changes were associated with strong decline in SCD1, FAS and ACC protein levels. Additionally, the level of carnitine palmitoyltransferase 1, a key enzyme involved in regulation of fatty acid betaoxidation, was substantially increased. Also the transcription factor associated with oxidation, peroxisome proliferators-activated receptor-alpha, was enhanced in rat liver after 16 weeks of TO feeding. These data show important differences in the effect of TO-rich diet on hepatic lipogenesis and beta-oxidation depending on feeding duration. While, shorter term feeding a TO-rich diet results in progression of lipogenesis, the long-term TO feeding leads to inhibition of lipogenesis and intensification of fat oxidation.